A comprehensive course covers the essential knowledge in biomedical implants. The goal is to provide students with the knowledge and skills to understand the clinical needs, the engineering principles, methodologies used in implant design, the resulting host-implant interaction, and the constraints, limitations on engineering design optimization, as well as the evaluation and assessment of the implant performance and clinical outcomes. Case studies include mechanical, bio-prosthetic and trans-catheter heart valves, vascular grafts, stents, pacemakers, orthopedic implants, dental implants, etc. The course also covers topics on regulatory issues, patent protection, design validation in animal models and clinical trials, IACUC, IRB, Good Manufacture Practice (GMP), and FDA regulations and approvals. Students are expected to be able to apply the learning to solve problems in the rapidly growing field of biomedical engineering.