This course introduces biomechanics as a means to describe mechanical behavior of biological tissues. A comprehensive course, it covers the fundamental concepts, experimental and theoretical approaches of biomechanics, and their applications in modern bioengineering, including mechano signal transduction, pathophysiology, tissue engineering and regeneration, medical implants, surgical intervention. Structural-mechanical properties of specific tissues, such as heart valves, cardiac tissues, blood vessels, tendon/ligament, skeletal muscles, cartilage, and meniscus will be discussed in great details. This course integrates the concepts of biomechanics, the underlying structural and biological mechanisms, illustrates how experimental, analytical and computational methods have been used to address clinical needs in enhancing the quality of health care delivery.