Topics include fundamentals of cell-ECM interactions, cell spreading, migration, proliferation and function; soft and hard tissue wound healing and nerve regeneration; polymer scaffolding materials and fabrication methods; cell-polymer interactions; in vitro and in vivo tissue culture and organ replacement. Students will be introduced to basic principles of pharmacokinetics and pharmacodynamics. Topics also include design and development of targeted and controlled drug delivery systems, including transdermal, inhalation, drug-eluting stents, stimulated-drug, as well as encapsulated nano and micro-particles for controlled release. Underlying principles of drug delivery, targeting, modification, distribution and diffusive transport will be discussed. Preferred background: satisfactory completion of BE 3380 (or co-requisite). Prerequisite: Accepted into the BE Professional Program or consent of the BE undergraduate advisor.